Therapeutic apheresis using a mononuclear cell program to lower the microfilaria burden of a 23-year-old African woman with loiasis
| Autor: | Michael E. Mitchell, Linda Welch, Brian Alexander, Robert Weinstein, Mindy Greene, Jeffrey A. Bailey, Michelle Vauthrin, Yong Zhao |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Blood volume 030204 cardiovascular system & hematology Hydroxyethyl starch Microfilaria Diethylcarbamazine 03 medical and health sciences 0302 clinical medicine Internal medicine parasitic diseases medicine 030212 general & internal medicine biology medicine.diagnostic_test business.industry Lumbar puncture Hematology General Medicine biology.organism_classification medicine.disease Surgery Apheresis business Loa loa Encephalitis medicine.drug |
| Zdroj: | Journal of Clinical Apheresis. 32:200-202 |
| ISSN: | 0733-2459 |
| DOI: | 10.1002/jca.21479 |
| Popis: | Apheresis has been used to lower the parasite burden of patients with Loa loa infection, but there are no reports regarding how to do this using modern, continuous flow equipment with a currently available program. A 23-year-old female refugee from Cameroon with known Loa loa infection presented to our Emergency Department with acute mental status changes and a picture of encephalitis. Lumbar puncture revealed Loa loa in her cerebrospinal fluid. Her midday blood microfilaria count was 15,000/mL. Because treatment with diethylcarbamazine was under consideration, we were asked to lower her parasite burden using apheresis. One single 2-total blood volume apheresis using the mononuclear cell program (without hydroxyethyl starch) on a COBE® Spectra Apheresis System decreased the microfilarial load from 15,000/mL to 10,666/mL, a 29% reduction. J. Clin. Apheresis 32:200-202, 2017. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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