Oral trivalent bismuth ions decrease, and trivalent indium or ruthenium ions increase, intestinal tumor burden in ApcΔ14/+mice
| Autor: | Mal Eutick, Graham S. Baldwin, Chelsea Dumesny, Marie Laval, Kathryn M. Marshall |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Chemistry Metals and Alloys Biophysics Biological activity Peptide hormone Biochemistry Orders of magnitude (mass) In vitro Biomaterials 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Ion binding Endocrinology Chemistry (miscellaneous) In vivo 030220 oncology & carcinogenesis Internal medicine Toxicity medicine Gastrin |
| Zdroj: | Metallomics. 10:194-200 |
| ISSN: | 1756-591X 1756-5901 |
| DOI: | 10.1039/c7mt00272f |
| Popis: | Immature forms of the peptide hormone gastrin have been implicated in the development of colorectal cancer (CRC). The biological activity of glycine-extended gastrin (Ggly) is dependent on the binding of Fe3+ ions in vitro and in vivo. The aim of the present study was to determine the effect of blocking Fe3+ ion binding to Ggly, using Bi3+, In3+ or Ru3+ ions, on the development of intestinal tumors in APCΔ14/+ mice. APCΔ14/+ mice were treated orally with Bi3+, In3+ or Ru3+ ions for up to 60 days, serum trace metals were analyzed by inductively coupled plasma mass spectrometry, and the incidence and size of intestinal tumors were assessed. Bi3+ treatment significantly decreased the number of tumors larger than 3 mm in male mice. In3+ or Ru3+ treatment significantly increased the tumor burden in all animals and In3+ increased the number of tumors larger than 3 mm or 5 mm in male mice alone. The fact that binding of In3+ or Ru3+ ions to Ggly was orders of magnitude stronger than the binding of Bi3+ ions implies that the inhibitory effect of Bi3+ ions is not a consequence of a reduction in Ggly activity. However, further testing of higher doses of Bi3+ ions for longer periods as an oral treatment for intestinal tumors is warranted. |
| Databáze: | OpenAIRE |
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