Severity of delayed ('secondary') cerebral energy failure after acute hypoxia-ischemia is related to the time integral of acute ATP depletion
| Autor: | Simon Roth, A. David Edwards, Marzena Wylezinska, Vincent Kirkbride, Chris E. Cooper, Juliet Penrice, Guy C. Brown, Donald Peebles, A Lorek, John S. Wyatt, Ernest B. Cady, E. Osmund R. Reynolds, Yakito Takei, H Owen-Reece, RF Aldridge, David T. Delpy |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Energy failure Radiological and Ultrasound Technology business.industry Metabolite Biophysics Ischemia Hypothermia medicine.disease Phosphocreatine chemistry.chemical_compound Endocrinology chemistry Internal medicine Anesthesia medicine Pi Radiology Nuclear Medicine and imaging Time integral medicine.symptom business Adenosine triphosphate |
| Zdroj: | Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine. 2:437-439 |
| ISSN: | 1352-8661 |
| DOI: | 10.1007/bf01705292 |
| Popis: | The aim of this study was to reproduce the delayed (“secondary”) cerebral energy failure previously described in birth-asphyxiated newborn infants and to investigate relationships between primary insult severity and the extent of the delayed energy failure. Phosphorus (31P) magnetic resonance spectroscopy (MRS) at 7 T was used to study the brains of 12 newborn piglets during an acute, reversible, cerebral hypoxic-ischemic episode which continued until nucleotide triphosphates (NTP) were depleted. After reperfusion and reoxygenation, spectroscopy was continued for 48 h. High-energy metabolite concentrations returned to near normal levels after the insult, but later they fell as delayed energy failure developed. The time integral of NTP depletion in the primary insult correlated strongly with the minimum [phosphocreatine (PCr)]/[inorganic orthophosphate (Pi)] observed 24–48 h after the insult. (Linear regression analysis gave slope −8.04 h−1; ordinate intercept=1.23;r=0.92;P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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