Increased Hemoglobin A1c Level Is Associated with a Better Outcome in Patients with Spontaneous Intracerebral Hemorrhage (P02.224)
| Autor: | Mohammad Moussavi, Mohammad Ibrahim, Usama Siddique, Martin Gizzi, Spozhmy Panezai, Jawad F. Kirmani, Daniel Korya |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Intracerebral hemorrhage
medicine.medical_specialty endocrine system diseases business.industry Blood volume medicine.disease nervous system diseases law.invention Randomized controlled trial Modified Rankin Scale law Diabetes mellitus Internal medicine Edema medicine In patient cardiovascular diseases Neurology (clinical) Spontaneous intracerebral hemorrhage medicine.symptom business |
| Zdroj: | Neurology. 78:P02.224-P02.224 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.78.1_meetingabstracts.p02.224 |
| Popis: | Objective: To study the relationship between hemoglobin A1c (HbA1c) levels and outcome in patients with intracerebral hemorrhage (ICH). Background HbA1c has become a key marker for chronicity and severity of diabetes mellitus (DM). Both diabetes and admission hyperglycemia in non-diabetic patients have been observed as predictors of poor outcome after spontaneous intracerebral hemorrhage (ICH). Hyperglycemia in acute stroke has been considered a manifestation of premorbid diabetic glucose metabolism. Few studies have looked at HbA1c and correlations with ICH outcome. Design/Methods: We conducted a retrospective analysis of ICH patients admitted in ICU between 2006 and 2009 at a community teaching hospital. Admission head CT and records were used to calculate ICH scores. Records were also evaluated for modified Rankin Scale at discharge (mRS), admission and discharge blood glucose levels. Patients were then divided into three groups as follows: (A)non-diabetics, (B)HbA1c=5-5.9; (C)HbA1c ≥6. ICH score and mRS were then compared to HbA1c levels and the means were computed between groups. Results: We studied 78 patients with the mean age of 69.21(SD=14.08; 56% male). The mean ICH scores were (A)=1.81 (N=32), (B)=1.77 (N=22), and (C)=1.08 (N=24). The mean difference was statistically significant (p Conclusions: As opposed to expected, our data showed inverse correlation between HbA1c levels and blood volume, edema volume, admission ICH score and discharge mRS. A further large scale, randomized study to correlate admission glucose level, HbA1c level and severity of ICH is needed. Disclosure: Dr. Ibrahim has nothing to disclose. Dr. Moussavi has nothing to disclose. Dr. Korya has nothing to disclose. Dr. Siddique has nothing to disclose. Dr. Panezai has nothing to disclose. Dr. Gizzi has nothing to disclose. Dr. Kirmani has nothing to disclose. |
| Databáze: | OpenAIRE |
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