Neurofibromatosis Type 1 or Von Recklinghausen Disease: About Three Cases to the National Hospital of Niamey and Literature Review

Autor:	S. Beydou, Eric Adehossi, Souleymane Brah, D. I. Bako, S. Sanoussi, Y. Abba Kaka, M. Sidibé, M. Konaté, M Daou, M. J. Y. Araoye, Z. Mamadou, A Andia, L Salissou
Rok vydání:	2021
Předmět:	medicine.medical_specialty Neurology biology business.industry General Medicine Scoliosis Consanguinity Disease medicine.disease Dermatology Neurofibromin 1 Orthopedic surgery biology.protein Medicine Neurofibromatosis business Congenital dysplasia
Zdroj:	Open Journal of Internal Medicine. 11:175-187
ISSN:	2162-5980 2162-5972
DOI:	10.4236/ojim.2021.113013
Popis:	We report three cases of neurofibromatosis type 1 disease with literature review, collected in the department of neurology and internal medicine from National Hospital of Niamey (HNN). Two of them were men and the first signs were noted by the mother at the birth in 2 cases. Only one case of consanguinity was observed. Clinically, light brown spots on the skin, neurofibromas, Lisch nodules were constantly observed. Histopathological’s exam confirmed neurofibromas. Moreover, cutaneous and ophthalmological manifestations lead to the diagnostic. Two cases of orthopedic complications were observed: one scoliosis and one Congenital dysplasia of the long bones. There was no specific treatment. Neurofibromatosis type 1 or von Recklinghausen’s disease is the most frequent phacomatosis and its diagnosis is usually composed of a set of clinical criteria of the National Institute Health (Bethesda, 1988).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ac2fe0f5214e04c9df99c6e9e197e22d https://doi.org/10.4236/ojim.2021.113013 Zobrazit plný text záznamu