| Popis: |
Estimating individual treatment effects (ITEs) is crucial to personalized psychotherapy. It depends on identifying all covariates that interact with treatment, a challenging task considering the many patient characteristics hypothesized to influence treatment outcome. The goal of this study was to compare different covariate selection strategies and their consequences of estimating ITEs. A Monte Carlo simulation was conducted to compare stepwise regression with and without cross-validation and shrinkage methods. The study was designed to mimic the setting of psychotherapy studies. No single covariate selection strategy dominated all others across all factor-level combinations and on all performance measures. Lasso showed the most accurate out-of-sample predictions, identified the highest number of true treatment-covariate interactions, and estimated ITEs with the highest precision across the most conditions. Domain backward stepwise regression and backward stepwise regression using BIC were least biased in estimating variance of ITEs across the most conditions. |
