Increased PLA2 activity in individuals at ultra-high risk for psychosis
| Autor: | Leda Leme Talib, Helena Passarelli Giroud Joaquim, Cícero A. C. Pereira, Martinus Theodorus van de Bilt, Wagner F. Gattaz, Alexandre Andrade Loch, Alana C. Costa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Psychosis biology business.industry Prodromal Syndromes General Medicine Ultra high risk medicine.disease 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Endocrinology Phospholipase A2 Internal medicine medicine biology.protein lipids (amino acids peptides and proteins) Pharmacology (medical) Platelet sense organs business 030217 neurology & neurosurgery Biological Psychiatry |
| Zdroj: | European Archives of Psychiatry and Clinical Neuroscience. 271:1593-1599 |
| ISSN: | 1433-8491 0940-1334 |
| DOI: | 10.1007/s00406-021-01246-y |
| Popis: | Phospholipase A2 is the main enzyme in the metabolism of membrane phospholipids. It comprises a family of enzymes divided into iPLA2, cPLA2 and sPLA2. Studies have reported increased PLA2 activity in psychotic patients, which suggests an accelerated breakdown of membrane phospholipids. In the present study we investigated whether increased PLA2 activity is also present in individuals at ultra-high risk (UHR) for psychosis. One-hundred fifty adults were included in this study (85 UHR and 65 controls). UHR was assessed using the “structured interview for prodromal syndromes”. PLA2 activity was determined in platelets by a radio-enzymatic assay. We found in UHR individuals increased activities of iPLA2 (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|