New Therapeutic Perspective for Bladder Cancer in Dogs: Toxicological and Clinical Effects of OncoTherad Nanostructured Immunotherapy
| Autor: | Wagner José Fávaro, Nelson Durán, S. H. S. Tizziani, Petra Karla Bockelmann |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
History medicine.medical_specialty Bladder cancer business.industry medicine.medical_treatment Ultrasound Urology Echogenicity Disease Immunotherapy medicine.disease Computer Science Applications Education 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Therapeutic index 030220 oncology & carcinogenesis medicine Effective treatment business Intravesical chemotherapy |
| Zdroj: | Journal of Physics: Conference Series. 1323:012022 |
| ISSN: | 1742-6596 1742-6588 |
| DOI: | 10.1088/1742-6596/1323/1/012022 |
| Popis: | Bladder cancer (BC) comprehends around 2% of all spontaneously occurring cancers in dogs. BC treatment remains a challenge since recurrence and progression of the disease, as well as the pronounced side effects associated to the available therapeutic modalities are present. In this scenario, a new perspective is represented by OncoTherad nanostructured immunomodulator. Thus, the aims of this study were to characterize and to evaluate the efficacy and possible toxicological effects of OncoTherad intravesical immunotherapy in 6 dogs with BC. Our results demonstrated that before the first instillation of OncoTherad, all dogs presented irregular tumor mass, mixed echogenicity, and hyperechoic echotexture, with a mean tumor volume of 9.38 cm3. After 6 instillations of OncoTherad, the tumor mass reduced 62.34% of its volume in relation to the initial ultrasound. At the end of 24 instillations, the tumor mass reduced 84.54% of its volume. Hematuria was decreased throughout OncoTherad treatment, disappearing on average after the eighteenth application and not returning after the last application. OncoTherad treatment showed no signs of systemic toxicity at the proposed therapeutic dose. In conclusion, OncoTherad intravesical immunotherapy seems a safe and effective treatment option for spontaneous canine bladder cancer and may provide benefit for preventing tumor recurrence. |
| Databáze: | OpenAIRE |
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