Determination of Amlodipine and Atenolol by Batch Injection Analysis with Amperometric Detection on Boron-doped Diamond Electrode
| Autor: | Almir A. Silva, Eduardo M. Richter, Rodrigo A.A. Munoz, Luiz A. J. Silva, Aline C. Oliveira |
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| Rok vydání: | 2016 |
| Předmět: |
Detection limit
Chromatography Working electrode Chemistry 010401 analytical chemistry 02 engineering and technology Electrolyte 021001 nanoscience & nanotechnology Atenolol 01 natural sciences High-performance liquid chromatography Amperometry 0104 chemical sciences Analytical Chemistry Dilution Electrode Electrochemistry medicine 0210 nano-technology medicine.drug |
| Zdroj: | Electroanalysis. 28:1455-1461 |
| ISSN: | 1040-0397 |
| DOI: | 10.1002/elan.201501138 |
| Popis: | This work describes the sequential determination of amlodipine (AML) and atenolol (ATN) by batch injection analysis (BIA) with pulsed amperometric detection (BIA-PAD). Boron doped diamond (BDD) was used as working electrode. AML was detected at +1.00 V and ATN at +1.65 V. The proposed BIA method is simple, robust, precise (RSD 70 injections h−1), generates reduced volume of waste (without use of organic solvent) and requires minimal sample manipulation (dissolution and dilution in electrolyte). The limits of detection were 0.074 and 0.073 µmol L−1 for AML and ATN, respectively. The results obtained with the proposed BIA method were compared to those obtained by HPLC and similar results were obtained (at 95% of confidence level). |
| Databáze: | OpenAIRE |
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