SHORT COMMUNICATION: Detection of complement regulatory proteins on soft contact lenses

Autor:	Loretta B. Szczotka, David S. Bardenstein, Sauer S, Medof Me
Rok vydání:	1997
Předmět:	Conjunctiva CD59 Biology eye diseases Sensory Systems Complement (complexity) Complement system Cell biology Contact lens Cellular and Molecular Neuroscience Ophthalmology medicine.anatomical_structure Cornea Immunology medicine Tears sense organs
Zdroj:	Current Eye Research. 16:1270-1273
ISSN:	1460-2202 0271-3683
DOI:	10.1076/ceyr.16.12.1270.5028
Popis:	PURPOSE. To determine whether the regulators of complement activation, decay-accelerating factor (DAF) and CD59, which have been identified on the cornea and conjunctiva and in soluble forms in tears and lacrimal secretions, are transferred to soft contact lenses worn by normal subjects. METHODS. Following overnight wear of group 4 extended-wear hydrophilic contact lenses by five normal subjects, we examined the lenses immunohistochemically for decay-accelerating factor (DAF) and CD59, two regulators which interfere with the complement cascade at the C3 and C9 steps, respectively. RESULTS. Both proteins were detected on all worn lenses but not on controls. CONCLUSIONS. These findings raise the question of whether these proteins, as do other contact lens-bound proteins, have deleterious effects, or to the contrary, if they maintain their natural activity, might they have protective functions for contact lens wearers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ac139c76be75da74a4ae1469baa7b720 https://doi.org/10.1076/ceyr.16.12.1270.5028 Zobrazit plný text záznamu