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Background: Chronic kidney disease (CKD) interacts with thyroid disease and cardiovascular disease (CVD). Our research aimed to analyze the correlation between echocardiographic parameters E / A, E / E ', E' / A ', LVEF and thyroid autoantibodies, and evaluate the role of thyroid autoimmunity in the development of CVD in patients with stages 3-5 CKD.Methods: The patients who were diagnosed as stages 3-5 CKD in our department from January 2015 to May 2019 were recruited. We collected the routine medical history, general clinical data, and laboratory test index of patients. Echocardiography is performed by a trained echocardiographer to measure mitral valve blood flow velocity (E) in early diastole and Mitral valve flow velocity (A), E / A ratio, mitral annulus velocity (E ') in early diastole, mitral annulus velocity (A') in end-diastole, E / E 'ratio, and E' / A ' ratio. The SPSS 22.0 statistical software was used to analyze the data.Results: A total of 1164 patients with stages 3-5 CKD were included. Thyroglobulin antibody (TGAb) was negatively correlated with eGFR (r = -0.287, P |