Evaluation of thrombolytic and monoclonal platelet GPIIb/IIIa receptor antibody therapy in refractory unstable angina pectoris: correlation between quantitative assessment of coronary angiograms and clinical course
| Autor: | Marcel van den Brand, Pim J. de Feyter, Maarten L. Simoons, Addy van Miltenburg, Menko J. de Boer |
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| Rok vydání: | 1994 |
| Předmět: |
Chemotherapy
medicine.medical_specialty medicine.diagnostic_test Unstable angina business.industry medicine.medical_treatment Clinical study design Heparin medicine.disease Angina Thrombolytic drug Internal medicine Angiography medicine Cardiology cardiovascular diseases Isosorbide dinitrate business medicine.drug |
| Zdroj: | Quantitative Coronary Angiography in Clinical Practice ISBN: 9789048142958 |
| Popis: | Despite the effort of Braunwald [1] to provide a classification of unstable angina, definitions still vary widely. Therefore it can hardly be surprising that patients included in clinical studies on unstable angina, show different outcomes, despite comparable study designs. Another potentially confounding factor in studies aiming at a reduction of cardiac events in patients with unstable angina is the time delay between onset of the syndrome, classified according to Braunwald, and the institution of therapy because a temporal relation has been demonstrated between the frequency of thrombi and the interval between angina at rest and angiography [2, 3]. A third variable making comparison of studies in patients with unstable angina dubious, is the therapy installed before a study drug is added to the drug regimen already routinely administered. As both antiplatelet agents [4, 5] and heparin [6] are efficacious in changing the clinical outcome of patients with unstable angina, the effect of administration of newer antiplatelet or thrombolytic drugs, night be influenced by these previously administered medications. |
| Databáze: | OpenAIRE |
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