Radioimmunoscintigraphy with Tc-99m-labelled SM3 in differentiating malignant from benign adnexal masses
| Autor: | M. Granowska, K.E. Britton, M.J. Carroll, P. van Trappen, A. Canizales, H. Jan, F. Nasreen, Ian Jacobs, N. Ali |
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| Rok vydání: | 2003 |
| Předmět: |
Gynecology
medicine.medical_specialty education.field_of_study business.industry Population Obstetrics and Gynecology Cancer medicine.disease medicine.anatomical_structure Adnexal Diseases False positive paradox medicine Radiology Differential diagnosis education Prospective cohort study business Ovarian cancer Pelvis |
| Zdroj: | BJOG: An International Journal of Obstetrics and Gynaecology. 110:508-514 |
| ISSN: | 1471-0528 1470-0328 |
| DOI: | 10.1046/j.1471-0528.2003.02186.x |
| Popis: | OBJECTIVE: Ultrasound scanning, serum CA125 and menopausal status have previously been combined in a risk of malignancy index for the differential diagnosis of adnexal masses. Although this approach has greater accuracy than either individual tests or clinical assessment, it has a significant false positive and false negative rate. Efforts have been directed at refining differential diagnosis and this study assessed the role of radioimmunoscintigraphy using the stripped mucin 3 (SM3) antibody that has a 17-fold greater uptake in malignant than benign ovarian tumours in vitro. DESIGN: Prospective study of patients with a pelvic mass using radioimmunoscintigraphy. SETTING: Department of Nuclear Medicine of St Bartholomew's Hospital in collaboration with Cancer Network. POPULATION: A total of 93 patients with pelvic masses were recruited for this study of which 32 had ovarian cancer and 61 had benign lesions. METHODS: Radioimmunoscintigraphy was performed with Tc-99m-labelled SM3 (600 MBq), anterior and posterior pelvis imaged at 10 minutes and at 4 and 24 hours and evaluated with change detection analysis and probability mapping. MAIN OUTCOME MEASURES: Sensitivity and specificity of radioimmunoscintigraphy for ovarian cancer. RESULTS: Radioimmunoscintigraphy had a sensitivity for ovarian cancer of 84% (27 true positive and 5 false negatives) and a specificity of 87% (53 true negatives and 8 false positives) giving a negative predictive value of 91%. CONCLUSION: These results suggest that radioimmunoscintigraphy could be used to reduce the number of false positive findings in a strategy to refine differential diagnosis of the pelvic mass. |
| Databáze: | OpenAIRE |
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