Low voltage-activated Ca2+ conductances in thalamic neurons

Autor: Ya. M. Shuba, Dmytro Isaev, A. N. Tarasenko, P. G. Kostyuk, A. V. Eremin, Stanislava O. Zhuravleva, A. V. Sotkis
Rok vydání: 1998
Předmět:
Zdroj: Neurophysiology. 30:194-198
ISSN: 1573-9007
0090-2977
DOI: 10.1007/bf02462811
Popis: Low voltage-activated (LVA) Ca2+ conductances were characterized in the neurons of the associative laterodorsal (LD) thalamic nucleus in rat brain slices and in enzymatically isolated thalamic units using electrophysiological techniques. Voltage dependence, kinetics of inactivation, pharmacology, and selectivity of the LVA current in the thalamic neurons from animals older than 14 postnatal days were consistent with the existence of two, “fast” and “slow,” subtypes of LVA Ca2+ channels. “Slow” LVA current in enzymatically isolated thalamic neurons was much less prominent, compared with that in slice neurons, suggesting that respective channels are predominatly located on the distal dendrites. “Fast” Ca2+ channels were sensitive to nifedipine (K d−2.6 μM) and La3+ (K d−1.0 mM), whereas “slow” Ca2+ channels were sensitive to Ni2+ (25 μM). Selectivity of the “fast” Ca2+ channels was similar to that found for the LVA Ca2+ channels in other preparations (I Ca:I Sr:I Ba−1.0: 1.23: 0.94), while selectivity of the “slow” Ca2+ channels more resembled selectivity of the HVA Ca2+ channels (I Ca:I Sr:I Ba−1.0: 2.5: 3.4).
Databáze: OpenAIRE
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