Treatment of Active Crohn’s Disease with Metronidazole or Sulfasalazine. A Preliminary Report of a Double Blind Controlled Trial [CCDSS]

Autor:	Anders Rosén, Ingemar Bergelin, Karin Ganrot-Norlin, Franz Bárány, Thor Alm, Urban Krause, Bo Ursing, Aud Krook, Gunnar Järnerot
Rok vydání:	1981
Předmět:	Crohn's disease medicine.medical_specialty business.industry Therapeutic effect Disease Uncontrolled Study medicine.disease Gastroenterology law.invention Metronidazole Randomized controlled trial law Sulfasalazine Multicenter trial Internal medicine medicine business medicine.drug
Zdroj:	Recent Advances in Crohn’s Disease ISBN: 9789400982758
DOI:	10.1007/978-94-009-8273-4_103
Popis:	In 1975 Ursing and Kamme (1) reported in an uncontrolled study, that metronidazole [M] had a therapeutic effect on Crohn’s disease. In two small studies this finding has both been disputed (2) and confirmed (3). As the need for better medical treatment of this disease is great a multicenter trial was set up and named: Cooperative Crohn’s Disease Study in Sweden [CCDSS]. The aim of the study was to investigate the clinical efficiency of treatment with metronidazole in active Crohn’s disease in comparison to treatment with sulfasalazine [S], that is to test the null hypothesis that metronidazole is not more effective than sulfasalazine.
Databáze:	OpenAIRE
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