Investigation of time clustering of congenital hypothyroidism in South-Eastern France: Is 1986 an abnormal year?
| Autor: | J. Sarles, C. Bonaldi, D. Delmas, A. Rogel, V. Goulet |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty Newborn screening Epidemiology business.industry Incidence (epidemiology) Thyroid Public Health Environmental and Occupational Health medicine.disease Thyroid dysgenesis Confidence interval Congenital hypothyroidism medicine.anatomical_structure medicine business Time clustering Hormone |
| Zdroj: | Revue d'Épidémiologie et de Santé Publique. 66:S332 |
| ISSN: | 0398-7620 |
| DOI: | 10.1016/j.respe.2018.05.254 |
| Popis: | Introduction Congenital hypothyroidism (CH) is a condition of thyroid hormone deficiency present at birth. Based on data recorded by the South-eastern France newborn screening center, an unusually large number of cases were observed in 1986, the year when radioactive iodine from the Chernobyl disaster was released. We sought to investigate the time clustering pattern of CH cases in this area using 31 years of data to study whether this cluster is unlikely to have arisen by chance. Methods The study included all cases of CH with eutopic thyroid gland and thyroid dysgenesis screened from 1982 to 2012 in Provence-Alpes-Cote-d’Azur and the island of Corsica. Statistical tests (Naus and Kulldorff scan tests) to retrospectively investigate an unusual temporal clustering of cases were applied, adjusting for the temporal incidence trend and variation of the neonatal population size. CH with eutopic thyroid gland were analyzed separately from thyroid dysgenesis, as an anomaly in thyroid development following radiation would be expected to present itself as thyroid dysgenesis. Results Thyroid dysgenesis was the underlying cause in 73% of the 522 cases of CH in newborn infants registered in the studied geographical area between 1982–2012. A statistically annual average increase was observed for CH with eutopic gland only (+3.4%, confidence interval: 1.2, 6.3). Irrespective of the type of CH or alternative hypothesis investigated for the clustering pattern, no statistically significant temporal clusters of cases were found. Conclusions Our results indicate that the perceived excess of cases in 1986 in South-Eastern France was not statistically unusual. This finding does not suggest a role for radioactive fallout of Chernobyl in the incidence of CH cases. |
| Databáze: | OpenAIRE |
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