Peptides and CCL11 and HMGB1 as molecular markers of aging: Literature review and own data

Autor:	Tarnovskaia Si, Khavinson VKh, Kuznik Bi, Natalia Linkova
Rok vydání:	2015
Předmět:	Eotaxin Tetrapeptide chemical and pharmacologic phenomena respiratory system Biology HMGB1 Ageing Immunology Gene expression Protein biosynthesis biology.protein Geriatrics and Gerontology Gerontology Gene CCL11
Zdroj:	Advances in Gerontology. 5:133-140
ISSN:	2079-0589 2079-0570
Popis:	Cytokines CCL11 (eotaxin) and HMGB1 (alarmin 1) are molecular markers of ageing and neurological, cardiovascular, and immune diseases. Created at the St. Petersburg Institute of Bioregulation and Gerontology, these short peptides are known to regulate gene expression and protein synthesis. They promote decreased mortality and deceleration of pathology in the elderly. The review suggests that the dipeptide vilon (Lys-Glu) and tetrapeptide epitalon (Ala-Glu-Asp-Gly) are involved in regulation of the CCL11 and HMGB1 genes as activators of their expression. The geroprotective effect of vilon and epitalon is probably due to the suppression of these genes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::abf38bd740d65ed7f5bb3f266ec267c6 https://doi.org/10.1134/s2079057015030078 Zobrazit plný text záznamu Full text from SpringerLink