Abstract 1358: Structure-based drug design of 3-site binding, high affinity inhibitors of S100B in malignant melanoma

Autor:	Michael C. Cavalier, David J. Weber, David J. Maloney, Mohd. Imran Ansari, Andrew Coop, Diane K. Luci, Alexander D. MacKerell, Ajit Jadhav, Paul T. Wilder, Lei Fang
Rok vydání:	2016
Předmět:	Oncology Drug Gerontology Cancer Research medicine.medical_specialty business.industry media_common.quotation_subject Melanoma Protein level Cancer medicine.disease Internal medicine medicine Structure based business media_common Predictive biomarker
Zdroj:	Cancer Research. 76:1358-1358
ISSN:	1538-7445 0008-5472
Popis:	An especially predictive biomarker when used in combination with other diagnostic indicators, S100B is elevated in >90% of malignant melanoma (MM) patients and its protein level correlates directly with poor survival ( Citation Format: Michael C. Cavalier, Paul T. Wilder, Diane Luci, David J. Maloney, Lei Fang, Mohd. Imran Ansari, Alexander D. MacKerell, Andrew Coop, Ajit Jadhav, David J. Weber. Structure-based drug design of 3-site binding, high affinity inhibitors of S100B in malignant melanoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1358.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::abe7fabe763d9905023fa059ed48bd27 https://doi.org/10.1158/1538-7445.am2016-1358 Zobrazit plný text záznamu