The Use of Samarium Enolates, A Novel Alternative in the Addition Reactions to Imines. Synthesis of 3-Amino Esters, Amides and Enantiopure 3,4-Diamino Esters

Autor:	Carmen Simal, Jose M. Concellon, Humberto Rodriguez‐Solla
Rok vydání:	2009
Předmět:	Samarium Addition reaction Enantiopure drug chemistry Amino esters chemistry.chemical_element Organic chemistry General Chemistry Mannich reaction
Zdroj:	Advanced Synthesis & Catalysis. 351:1238-1242
ISSN:	1615-4169 1615-4150
Popis:	An efficient reaction of tosylimines with a range of samarium enolates (derived from esters, and amides) is reported. The reaction with the α-dibenzylamino-N-tert-butanesulfinimine derived from chiral phenylalaninal afforded the corresponding enantiopure 3,4-diamino ester with very high diastereoselectivity.
Databáze:	OpenAIRE
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