Cobalt-Catalyzed Oxidative C(sp3)–H Phosphonylation for α-Aminophosphonates via C(sp3)–H/P(O)–H Coupling

Autor:	Yiqun Cui, Rongcan Lin, Mei-Juan Fang, Shanshan Shi, Yufen Zhao, Guo Tang, Binzhou Lin
Rok vydání:	2018
Předmět:	010405 organic chemistry Organic Chemistry chemistry.chemical_element Oxidative phosphorylation 010402 general chemistry 01 natural sciences Medicinal chemistry Coupling reaction 0104 chemical sciences Catalysis Coupling (electronics) Cobalt acetate chemistry Cobalt
Zdroj:	The Journal of Organic Chemistry. 83:6754-6761
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.8b00674
Popis:	The first oxidative C(sp3)–H phosphonylation of tertiary aliphatic amines has been developed. The use of cobalt acetate as a catalyst, N-hydroxyphthalimide as a cocatalyst, and air as an oxidant enabled the conversion of tertiary aromatic and aliphatic amines into α-aminophosphonates in moderate to excellent yields under mild conditions via a cross dehydrogenative coupling reaction.
Databáze:	OpenAIRE
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