An electrophysiological investigation of the state of the central nervous system in experimental brucellosis
| Autor: | I. I. Polyakov, K. M. Mokhin |
|---|---|
| Rok vydání: | 1962 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Central nervous system Brain cortex Brucellosis General Medicine INFECTIOUS PROCESS Brucella Electroencephalography Biology medicine.disease biology.organism_classification General Biochemistry Genetics and Molecular Biology Electrophysiology medicine.anatomical_structure medicine Bacteriology |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 53:167-171 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00787114 |
| Popis: | Experiments were performed on guinea pigs infected withBr. melitensis strains. Cerebral biocurrents and immunobiological reactivity were studied in dynamics. Already on the 3rd–5th day after the injection the presence of an electrophysiological reaction of the brain cortex was noted in the form of marked activation of the biopotentials; on the 10th–11th day it was replaced by depression of biocurrents. Later, in the majority of experiments there was a considerable increase of the biocurrent amplitude with the appearance of slow waves (2–5 per sec.). Such EEG shifts are the most marked at the chronic stage of the disease. Comparative investigation of the functional CNS state, immunobiological reactivity, infectious process bacteriology, and body temperature in brucellosis infected guinea pigs have demonstrated that the first response to invasion of brucella into the organism were changes in the central nervous system, followed by corresponding shifts in immunobiological reactivity and thermocontrol. |
| Databáze: | OpenAIRE |
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