Heparin Cofactor II Deficiency in Patients Infected with the Human Immunodeficiency Virus
| Autor: | Didier Sicard, M E Holleman, I Ledjev, M Lamine, T. Guez, P. Toulon, Daniel Sereni |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Heparin cofactor II
medicine.medical_specialty education.field_of_study biology medicine.drug_class Lymphocyte Anticoagulant Population Hematology medicine.disease Protein S medicine.anatomical_structure Endocrinology Antigen Internal medicine Immunology Blood plasma medicine biology.protein education Immunodeficiency |
| Zdroj: | Thrombosis and Haemostasis. 70:730-735 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0038-1649660 |
| Popis: | SummaryIn human plasma, heparin cofactor II (HCII) is a thrombin inhibitor, whose deficiency has been reported to be associated with recurrent thrombosis. The finding of two cases of low plasma HCII activity in two patients infected with the human immunodeficiency virus (HIV) led us to investigate this coagulation inhibitor in the plasma of a larger population of HIV-infected patients. The mean plasma HCII activity was significantly lower in 96 HIV-infected patients than in 96 age- and sex-matched healthy individuals (0.75 ± 0.24 vs 0.99 ± 0.17 U/ml, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|