Effect of Adjuvant Vitamin C on Brain-Derived Neurotrophic Factor Levels and Improvement of Negative Symptoms in Schizophrenic Patients
| Autor: | Herwina Sabaruddin, Kristian Liaury, Andi Alfian Zainuddin, Andi J. Tanra |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Brain-derived neurotrophic factor
Vitamin medicine.medical_specialty Vitamin C business.industry medicine.medical_treatment General Medicine medicine.disease University hospital Gastroenterology Examination method chemistry.chemical_compound chemistry Schizophrenia Internal medicine medicine Serum vitamin C business Adjuvant |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences. 9:353-357 |
| ISSN: | 1857-9655 |
| DOI: | 10.3889/oamjms.2021.7086 |
| Popis: | AIM: This study aims to determine the effect of adjuvant Vitamin C on brain-derived neurotropic factors (BDNF) levels and improvement of negative symptoms in schizophrenic patients. METHODS: This study was conducted at Hasanuddin University Hospital and its affiliate with 60 schizophrenic patients (30 controls, 27 treatments, and three dropout patients). The ELISA sample examination method was used to examine blood levels of BDNF, and Vitamin C levels before and after administration of Vitamin C. In addition, the negative symptoms were measured using the PANSS score. RESULTS: There was a significant increase in BDNF levels in treatments group compared the control at 4th–8th weeks with p = 0.005 (4th week) and ≤0.0001 ( |
| Databáze: | OpenAIRE |
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