| Autor: |
Lilian Leite Fausto, Adriano Alberti, Gabriela Kades, Risoní Pereira Dias de Carvalho, Viviane Freiberger, Leticia Ventura, Paula Dias, Eliton Marcio Zanoni, Ben Hur Soares, Matheus Luchini Dutra, Daniel Fernandes Martins, Clarissa Martinelli Comim |
| Rok vydání: |
2022 |
| Popis: |
Duchenne muscular dystrophy (DMD) is one of the X-linked recessive progressive muscular dystrophies, characterized by progressive degeneration of skeletal muscle and multisystemic involvement, including the central nervous system (CNS). To investigate the effects of DCet on biochemical and clinical parameters in a mouse model with DMD. Methods: Young adult mice (50 days old) were fed DCet for 14 days; control groups received a standard diet for the same period. On the 14th day of exposure to diets, each mouse was submitted to memory and behavior evaluation tests. After the behavioral tests, the animals were sacrificed for biochemical evaluation of oxidative stress and levels of inflammatory biomarkers. Body weight, feed intake and BDNF levels were also evaluated. Results: mdx+DCet mice had less mass (0.2g ± 2.49) and presented memory retention (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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