Neuroprotective Activity of Docosahexaenoic Acid in the Central and Peripheral Nervous System after Chronic Constriction Injury of the Sciatic Nerve
| Autor: | Igor Manzhulo, I. V. Dyuizen, Olga Manzhulo, Sergey P. Kasyanov, Anna Starinets, Anna A. Tyrtyshnaia |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Analgesic Biochemistry Neuroprotection 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine medicine Molecular Biology biology business.industry Spinal cord Myelin basic protein 030104 developmental biology medicine.anatomical_structure Endocrinology nervous system Docosahexaenoic acid Peripheral nervous system Constriction injury biology.protein Sciatic nerve business 030217 neurology & neurosurgery |
| Zdroj: | Neurochemical Journal. 14:101-107 |
| ISSN: | 1819-7132 1819-7124 |
| Popis: | —The analgesic and neuroprotective activity of docosahexaenoic acid (DHA, 22:6 n-3) was studied in a model of rat chronic constriction injury of the sciatic nerve. We characterized the morphological and chemical state of the distal sciatic nerve segment and the activity of GFAP-positive astroglia and SP-ergic nerve fibers on the 7th and 28th day after the operation. It was found that DHA improves the morphological state of the sciatic nerve, prevents the degradation of the myelin basic protein and stabilizes the activity level of astroglia and SP-positive nerve fibers in the surface plates of the posterior horns of the spinal cord. In general, DHA has a complex effect on the course of the post-traumatic process in the central and peripheral nervous system, which indicates its high therapeutic potential. |
| Databáze: | OpenAIRE |
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