| Autor: |
Lingam Venkata Reddy, Mamatha Nakka, Madeleine Helliwell, Sarbani Pal, Alishetty Suman, Soumen Ghosh, Khagga Mukkanti, Alok Kumar Mukherjee |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Journal of Heterocyclic Chemistry. 48:555-562 |
| ISSN: |
0022-152X |
| DOI: |
10.1002/jhet.618 |
| Popis: |
Reduction of nimesulide followed by treating the N-acyl derivative of resulting arylamine with Vilsmeier-Haack reagent provided novel 2-chloro-3-formylquinoline derivatives. The construction of quinoline ring using Vilsmeier-Haack reagent afforded an unexpected compound, N-(2-chloro-3-formyl-7-phenoxy quinolin-6-yl)formamide, in addition to the expected product. The structure of this unexpected quinoline derivative was established via single-crystal X-ray analysis and its formation could be explained by an unprecedented N-S bond cleavage under Vilsmeier-Haack reaction conditions. The 2-chloro-3-formylquinoline derivatives obtained were converted to a number of corresponding Schiff bases with potential pharmacological importance. J. Heterocyclic Chem., 2011. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
