Effect of Timing on the Administration of Spherical Charcoal (Kremezin) on the Pharmacokinetics of Valproic Acid in Rats

Autor:	Masayuki Sakai, Nobuo Hokama, Susumu Ohshiro, Matao Sakanashi, Hiromasa Kameya, Norio Hobara
Rok vydání:	2003
Předmět:	Valproic Acid Chemistry Sodium Cmax chemistry.chemical_element Absorption (skin) Pharmacology Pharmacokinetics visual_art Plasma concentration medicine visual_art.visual_art_medium lipids (amino acids peptides and proteins) Dosing Charcoal medicine.drug
Zdroj:	Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 29:491-494
ISSN:	1882-1499 1346-342X
DOI:	10.5649/jjphcs.29.491
Popis:	The effect of timing on the administration of spherical charcoal (Kremezin) on the pharmacokinetics of valproic acid (VPA) in the coadministration of sodium valproate and Kremezin was examined in rats.Kremezin, when administered either immediately or 30 min after the administration of sodium valproate, significantly decreased the area under the plasma concentration-time curve (AUC) 0-3 of VPA by about 30%. In addition, when Kremezin was administered 30 min or 1 hr before sodium valproate dosing it decreased the maximum plasma concentration (Cmax) of VPA by 39% and 27%, respectively, and significantly decreased the AUC0-3 of VPA by 54% and 45%, respectively. The plasma VPA concentrations in all Kremezin-treated groups were significantly lower than those in the controls. However, Kremezin administered 1 hr after sodium valproate dosing had no effect on the plasma VPA concentration, Cmax or AUC0-3 of VPA.These results suggest that Kremezin decreased the absorption of VPA due to adsorption after the coadministration of sodium valproate and Kremezin.
Databáze:	OpenAIRE
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