A Convenient Synthesis of α-Substituted β,γ-Unsaturated Ketones and Esters via the Direct Addition of Substituted Allylic Zinc Reagents Prepared by Direct Insertion
| Autor: | Christoph Sämann, Paul Knochel |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Allylic rearrangement
010405 organic chemistry Organic Chemistry chemistry.chemical_element Halide Regioselectivity Zinc 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 3. Good health 0104 chemical sciences Metal chemistry Reagent Yield (chemistry) visual_art visual_art.visual_art_medium |
| Zdroj: | Synthesis. 45:1870-1876 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0033-1338415 |
| Popis: | A practical and convenient procedure for the synthesis of α-substituted β,γ-unsaturated ketones and esters has been developed. Substituted allylic zinc reagents, prepared via direct metal insertion in substituted allylic halides, react readily with a broad range of acid chlorides and chloroformates furnishing the corresponding α-substituted β,γ-unsaturated ketones and esters in high yield and perfect regioselectivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|