ChemInform Abstract: Synthesis of Some Piperazinylpyrazolo[3,4-b]pyridines as Selective Serotonin Re-Uptake Inhibitors

Autor:	Joachim E. Roehr, Gregory M. Shutske
Rok vydání:	2010
Předmět:	chemistry Stereochemistry organic chemicals Fluorine chemistry.chemical_element heterocyclic compounds General Medicine Serotonin
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199745158
Popis:	A number of 3-substituted 6-piperazinylpyrazolo[3,4-b]pyridines were synthesized from 2,6-difluoropyridine by directed ortho metallation and sequential intra- and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3-position showed activity as selective serotonin re-uptake inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aba3b328ba875bcdfe3a414da8766e47 https://doi.org/10.1002/chin.199745158 Zobrazit plný text záznamu Plný text