Interaction study of acetylcholinestrase inhibitors on pharmacokinetics of memantine in rat plasma by HPLC-fluorescence method
| Autor: | Naotaka Kuroda, Horria A. Mohamed, Kenichiro Nakashima, Rie Ikeda, Hanaa M. Abdel-Wadood, Mitsuhiro Wada, Mohamed G. Hassan |
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| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
Single administration Chromatography Hydrochloride Clinical Biochemistry Significant difference Memantine General Medicine Biochemistry Analytical Chemistry chemistry.chemical_compound Pharmacokinetics chemistry Hplc fluorescence Drug Discovery medicine Donepezil Molecular Biology medicine.drug |
| Zdroj: | Biomedical Chromatography. 27:1685-1689 |
| ISSN: | 0269-3879 |
| DOI: | 10.1002/bmc.2980 |
| Popis: | The present study aims to investigate the possibility of interaction of donepezil (DP) and galantamine (GAL) as acetylcholinestrase inhibitors, on memantine (MT) hydrochloride in rat plasma by HPLC-fluorescence detection. The separation of MT was achieved within 12 min without interference of DP and GAL on the chromatogram. MT levels in rat plasma with a single administration of MT (2.5 mg/kg, i.p.) and those with a co-administration of DP (5.0 mg/kg, i.p.) and GAL (3 mg/kg, i.p.) were monitored. MT concentrations determined in rat plasma ranged from 10.0 to 245.6 ng/mL. Significant difference was observed in the behavior of MT with a co-administration of DP, while no significant difference was observed with a co-administration of GAL. |
| Databáze: | OpenAIRE |
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