Efficacy of topical 0.3% ciprofloxacin application in reducing the conjunctival biota of patients undergoing cataract extraction
| Autor: | L. Ramirez, H. Mino de Kaspar, R. Sanabria, Florentina Laspina, Norma Fariña, J. Carron, Agustin Carron, D. Cibils, Margarita Samudio |
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| Rok vydání: | 2013 |
| Předmět: |
Colony-forming unit
Conjunctiva business.industry medicine.drug_class medicine.medical_treatment Antibiotics General Medicine Cataract surgery Agar plate Cataract extraction Ciprofloxacin Chocolate agar chemistry.chemical_compound medicine.anatomical_structure chemistry Anesthesia Medicine business medicine.drug |
| Zdroj: | Archivos de la Sociedad Española de Oftalmología (English Edition). 88:345-351 |
| ISSN: | 2173-5794 |
| DOI: | 10.1016/j.oftale.2013.01.002 |
| Popis: | Objective To determine the efficacy of topical 0.3% ciprofloxacin in reducing conjunctival biota in patients undergoing cataract surgery. Patients and methods Experimental, prospective, randomized, controlled and single-blind study. Forty-six eyes of 46 patients were randomized into 2 groups, the study group (n = 23) received topical 0.3% ciprofloxacin one day before surgery for six times, and on the day of the surgery one drop every 15 min starting 1 h before surgery until 3 doses were completed. The control group (n = 23) did not receive any antibiotics. For both groups for the surgical field 10% povidone-iodine was applied. Samples from the conjunctiva were taken at four different times and then cultured on solid media (chocolate agar, blood agar) and enrichment broth (thioglycolate). The aqueous humor samples were also cultured in thioglycolate. The presence of bacteria was identified quantitatively and qualitatively, and the frequency of contamination was measured by considering the presence of bacteria in liquid and solid culture media. The number of colony forming units (CFU) was counted in the solid culture medium. Results Positive cultures were obtained in 82.6% and 78.2% of the patients in the study and control groups, respectively, before the administration of 0.3% ciprofloxacin. The administration of 0.3% ciprofloxacin significantly reduced the CFU compared to the control group (p Conclusion The administration of 0.3% ciprofloxacin reduces conjunctival bacterial load in the preoperative period. However, it was unable to eradicate the bacteria completely. The administration of povidone-iodine reduced conjunctival biota in 50–70% of patients undergoing cataract surgery. |
| Databáze: | OpenAIRE |
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