The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice

Autor:	Phillip L. Evans, Saroop S. Matharu, Scott A. Raybuck, David Kay, Yu-Ping Luong, Lauffer David J, Murcko Mark A, David J. Livingston, Mullican Michael D, Golec Julian M C, Roger John Gillespie, Geoffrey M. Porritt
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Tetrapeptide Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Methylation Biochemistry Aldehyde chemistry.chemical_compound Enzyme chemistry Amide Drug Discovery Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 4:2359-2364
ISSN:	0960-894X
DOI:	10.1016/0960-894x(94)85040-2
Popis:	The tetrapeptide aldehyde Ac-Tyr-Val-Ala-AspH ( 1 , L-709,049) has been reported to be a potent reversible inhibitor of Interleukin-1β Converting Enzyme (ICE). We have prepared a series of analogs of 1 , in order to explore the active sige of ICE. The effects of truncation, methylation of the amide nitrogens and modification of the aldehyde group of 1 are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ab93ad698808a5cf3b6d4bee3e5c5c3d https://doi.org/10.1016/0960-894x(94)85040-2 Zobrazit plný text záznamu