Structure-Activity Relationship and Pharmacological Evaluation of 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenylacetamide as Cholesterol Ester Transfer Protein Inhibitor
| Autor: | Mingyue Zhang, Xiaohui Lin, Jianping Li, Ji-yan Zhang, Xiao Hu, Yi Zhang, Qian Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Drug biology 010405 organic chemistry media_common.quotation_subject Resveratrol 01 natural sciences Combinatorial chemistry 0104 chemical sciences Matrix (chemical analysis) 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Cholesterylester transfer protein biology.protein Structure–activity relationship General Pharmacology Toxicology and Pharmaceutics Glycoprotein media_common |
| Zdroj: | Revista Brasileira de Farmacognosia. 30:350-356 |
| ISSN: | 1981-528X |
| DOI: | 10.1007/s43450-020-00022-8 |
| Popis: | Cholesterol ester transfer protein is a plasma glycoprotein synthesized by the liver. Inhibitors of this protein have been researched to treat dyslipidemia. The purpose of this study was to use the computer-aided drug design technique to screen the structures of compounds from the traditional Chinese medicine database and optimize them as new cholesterol-lowering drugs. Molecular docking using 248 chemical compositions of traditional Chinese medicines with cholesterol ester transfer protein was performed. The parent structure “resveratrol” was selected and optimized as the matrix structure. A series of 4-[2-(3,5-dimethoxy-phenyl)-vinyl]-phenylamine analogues were synthesized and characterized by spectroscopic and spectrometric methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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