Microwave-induced calcium(II) chloride-catalyzed Paal–Knorr pyrrole synthesis: a safe, expeditious, and sustainable protocol

Autor:	Saeed Rastgar, Farshid Mohsenzadeh, Kioumars Aghapoor, Hossein Reza Darabi
Rok vydání:	2018
Předmět:	010405 organic chemistry Knorr pyrrole synthesis chemistry.chemical_element General Chemistry Calcium 010402 general chemistry Alkali metal 01 natural sciences Chloride 0104 chemical sciences Catalysis Lewis acid catalysis chemistry Microwave irradiation medicine Organic chemistry Microwave medicine.drug
Zdroj:	Research on Chemical Intermediates. 44:4063-4072
ISSN:	1568-5675 0922-6168
DOI:	10.1007/s11164-018-3355-7
Popis:	Among various alkali (Na, K) and alkaline-earth (Ca, Mg, Sr, Ba) chlorides, calcium(II) chloride was found to be a cost-effective Lewis acid catalyst for solvent-free synthesis of pyrroles from primary aromatic and aliphatic amines under open-vessel focused microwave irradiation. The salient features of this environmentally benign method are high to quantitative conversion, short reaction time, safe and clean reaction profile, possibility of scale-up to multigram quantities, and use of a low-cost, widely available, nontoxic catalyst.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ab8fa6c93675330a83d6225caa3a935b https://doi.org/10.1007/s11164-018-3355-7 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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