Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis
| Autor: | Adaku C. Ume, Tara Y. Wenegieme, Jennae N. Shelby, Chiagozie D. B. Paul-Onyia, Aston M. J. Waite, John K. Kamau, Danielle N. Adams, Keiichiro Susuki, Eric S. Bennett, Hongmei Ren, Clintoria R. Williams |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | American Journal of Physiology-Renal Physiology. 324:F433-F445 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.00226.2022 |
| Popis: | Renal fibrosis, a detrimental feature of irreversible kidney damage, remains a sinister consequence of long-term calcineurin inhibitor (CNI) immunosuppressive therapy. Our study not only incorporates renal fibroblasts into the growing list of cell types negatively impacted by CNIs but also identifies renal fibroblast-to-myofibroblast transition as a process mediated via a TGF-β-dependent mechanism. This insight will direct future studies investigating the feasibility of inhibiting TGF-β signaling to maintain CNI-mediated immunosuppression while ultimately preserving kidney health. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|