Freeze Dried Biodegradable Polycaprolactone/Chitosan/Gelatin Porous Scaffolds for Bone Substitute Applications
| Autor: | Saeed Kahrobaee, Javad Esmaeilzadeh, Mahsa Haghbin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
food.ingredient Polymers and Plastics Bone substitute General Chemical Engineering Organic Chemistry technology industry and agriculture 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Gelatin 0104 chemical sciences Chitosan Freeze-drying chemistry.chemical_compound food chemistry Chemical engineering Polycaprolactone Materials Chemistry MTT assay Fourier transform infrared spectroscopy 0210 nano-technology Porosity |
| Zdroj: | Macromolecular Research. 28:1232-1240 |
| ISSN: | 2092-7673 1598-5032 |
| DOI: | 10.1007/s13233-020-8170-5 |
| Popis: | In current work, the porous 3D bone substitute scaffolds based on the chitosan, gelatin and polycaprolactone using freeze drying technique are introduced. SEM images showed that all the scaffolds had porous structures with average pore diameter size of 23–183 µm. The results of FTIR demonstrated the successful blending of scaffolds. Also, the compression test results determined that the presence of polycaprolactone effectively improved the mechanical properties of the chitosan/gelatin/polycaprolactone scaffolds, having the highest strength, i.e. 24.5 MPa and highest modulus, i.e. 3.86 MPa. The degradation behavior obtained under lysozyme/PBS solutions revealed that the chitosan/gelatin scaffold had a faster degradation rate rather than other scaffolds. MTT assay as well as cell attachment analysis confirmed the appropriate cell viability and cell adhesion on the scaffolds. Taken together, the scaffolds developed in this study may find potential application in bone substitution applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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