Impact of LDL Cholesterol on Microvascular Versus Macrovascular Disease
| Autor: | Frida Emanuelsson, Børge G. Nordestgaard, Marianne Benn, Anne Tybjærg-Hansen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Statin business.industry medicine.drug_class Population 030204 cardiovascular system & hematology medicine.disease Coronary artery disease 03 medical and health sciences 0302 clinical medicine Meta-analysis Internal medicine Mendelian randomization medicine lipids (amino acids peptides and proteins) 030212 general & internal medicine Cardiology and Cardiovascular Medicine business education Kidney disease Macrovascular disease Retinopathy |
| Zdroj: | Journal of the American College of Cardiology. 74:1465-1476 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2019.07.037 |
| Popis: | Background Low-density lipoprotein cholesterol (LDL-C) is causally associated with a high risk of coronary artery disease. Whether this also holds for a spectrum of peripheral vascular diseases is unknown. Objectives The purpose of this study was to determine whether high LDL-C causally relates to risk of retinopathy, neuropathy, chronic kidney disease (CKD), and peripheral arterial disease (PAD) in the general population. Methods One-sample Mendelian randomization (MR) of 116,419 Danish individuals, 2-sample MR on summary-level data from the Global Lipid Genetics Consortium (GLGC) (n = 94,595) and the UK Biobank (n = 408,455), and meta-analysis of randomized statin trials (n = 64,134) were performed. Results Observationally, high LDL-C did not associate with high risk of retinopathy or neuropathy. There were stepwise increases in risk of CKD and PAD with higher LDL-C (both p for trend Conclusions High LDL-C was not causally associated with risk of retinopathy and neuropathy; however, high LDL-C was observationally and genetically associated with high risks of PAD and CKD, suggesting that LDL-C is causally involved in the pathogenesis of these diseases. |
| Databáze: | OpenAIRE |
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