A novel chromium trioxide catalyzed oxidation of primary alcohols to the carboxylic acids

Autor:	Paul J. Reider, Mangzhu Zhao, D. M. Tschaen, Edward J. J. Grabowski, Richard Desmond, Zhiguo Song, Jing Li
Rok vydání:	1998
Předmět:	Chromium trioxide Primary (chemistry) Chemistry viruses Organic Chemistry chemistry.chemical_element Biochemistry Catalysis chemistry.chemical_compound Chromium Yield (chemistry) Drug Discovery Organic chemistry Racemization
Zdroj:	Tetrahedron Letters. 39:5323-5326
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)00987-3
Popis:	A novel CrO 3 catalyzed oxidation of primary alcohols to the carboxylic acids is reported. The oxidation proceeds smoothly with only 1–2 mol % of CrO 3 and 2.5 equivalents of H 5 IO 6 in wet MeCN to give the carboxylic acids in excellent yield. No significant racemization is observed for alcohols with adjacent chiral centers. Secondary alcohols are cleanly oxidized to ketones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ab79c5cd6b482960de09135223700910 https://doi.org/10.1016/s0040-4039(98)00987-3 Zobrazit plný text záznamu Full Text from ScienceDirect