Sesquiterpenes and Steroids from an Endophytic Eutypella scoparia
| Autor: | Yan Chen, Zhen-Xing Zou, Sha Zhang, Wenge Zhang, Haibo Tan, Luqiong Huo, Xiuxiang Lu |
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| Rok vydání: | 2021 |
| Předmět: |
Eutypella scoparia
Circular dichroism Stereochemistry medicine.medical_treatment Pharmaceutical Science medicine.disease_cause 01 natural sciences Analytical Chemistry Steroid Triterpenoid Drug Discovery medicine Pharmacology biology 010405 organic chemistry Chemistry Organic Chemistry Endophytic fungus biology.organism_classification Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Staphylococcus aureus Molecular Medicine Antibacterial activity |
| Zdroj: | Journal of Natural Products. 84:1715-1724 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | A chemical investigation on the EtOAc extract of the endophytic fungus Eutypella scoparia SCBG-8 led to the isolation of eight new sesquiterpenes eutyscoparins A-H (1-8), one C-28 steroid eutyscoparene A (9), one triterpenoid eutyscoparene B (10), six known terpenoids, and two known steroids. Their structures including absolute configurations were established on the basis of spectroscopic data analysis, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Compound 7 displayed antibacterial activity against S. aureus and MRSA (methicillin-resistant Staphylococcus aureus) with MIC values of 6.3 μg/mL. |
| Databáze: | OpenAIRE |
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