Stimulation of [3H]spiroperidol binding after prolonged neuroleptic therapy by the cholecystokinin octapeptide analog cerulein
| Autor: | M. O. Maimets, Nurk Am, Eero Vasar, L. Kh. Allikmets |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Chemistry medicine.medical_treatment Stimulation General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Apomorphine Endocrinology Dopamine Internal medicine Cardiovascular agent medicine Morphine Serotonin Antipsychotic hormones hormone substitutes and hormone antagonists medicine.drug Cholecystokinin |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 99:87-89 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00806622 |
| Popis: | Evidence has recently been obtained that cholecystokinin and its analog cerulein have marked antipsychotic action on patients with schizophrenia who are resistant to neuroleptics; this is the basis for interest in this study of the effect of cerulein, a high-affinity analog of the octapeptide cholecystokinin, on binding of tritium-spiroperidol in vivo. Considering the apormorphine-like action of cerulein, this biochemical analysis was undertaken in the form of a comparative study with N-propyl-norapomorphine, a high-affinity analogy of apomorphine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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