| Autor: |
M. Ootsuka, S.-I. Tate, Isao Ono, H. Fujiki, N. Nakashima, Norihiko Ono |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
IEEE Congress on Evolutionary Computation |
| DOI: |
10.1109/cec.2002.1006251 |
| Popis: |
Protein three-dimensional structure determination is one of the most important problems in molecular biology. Nuclear magnetic resonance (NMR) spectroscopy is one of the promising techniques capable of determining the three-dimensional structures of proteins at atomic resolution. In determining protein structures using NMR spectroscopy, nuclear Overhauser effect (NOE) signal assignment is the most laborious and time-consuming process. Attempts to automate NOE signal assignment have failed so far. In this paper, we propose a new automatic assignment method of NOE signals based on a real-coded genetic algorithm and examine its effectiveness by applying it to determining the structure of an /spl alpha/-helix, which is a well-known common substructure of proteins, and a protein called HMG2B. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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