Crystal structure and DNA binding studies of a cobalt(II) complex containing mixed-ligands of 1, 10-phenathroline and glycollic acid

Autor:	Qing Xiang Wang, Hai Bin Lin, Cong Min Zhang, Wen Qi Li
Rok vydání:	2011
Předmět:	Absorption spectroscopy Chemistry Stereochemistry Intercalation (chemistry) chemistry.chemical_element General Chemistry Crystal structure Electrochemistry Crystallography chemistry.chemical_compound Titration Absorption (chemistry) Cobalt DNA
Zdroj:	Chinese Chemical Letters. 22:969-972
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2011.03.003
Popis:	A cobalt(II) complex containing mixed-ligands of 1, 10-phenathroline (phen) and glycollic acid (GA), [Co(GA)2(phen)] was synthesized and its structure was characterized by X-ray diffraction. The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods. Electronic absorption spectrum experiments showed that after interaction with DNA, the characteristic absorption peaks of [Co(GA)2(phen)] underwent hypochromic effect as well as red-shift. Also, the binding strength of 3.8 × 104 L/mol was estimated by titration method. Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA. All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ab28ab8718f2c8c3ee70500cbda3c307 https://doi.org/10.1016/j.cclet.2011.03.003 Zobrazit plný text záznamu Full Text from ScienceDirect