The 5‐HT1Areceptor agonist, 8‐OH‐DPAT, attenuates long‐lasting pain in imiquimod‐induced psoriasis in mice
| Autor: | Miguel Avalos-Viveros, Claudia Cervantes-Durán, Alain-Raimundo Rodríguez-Orozco, Luz Torner, Héctor-Eduardo Martínez-Flores, Sandra-Guadalupe Sánchez-Ceja, Martha Estrella García-Pérez |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Experimental Dermatology. 31:600-607 |
| ISSN: | 1600-0625 0906-6705 |
| DOI: | 10.1111/exd.14492 |
| Popis: | Psoriasis pain is a common symptom underestimated and rarely evaluated in psoriasis clinical trials. This work aimed to investigate whether the development of secondary chronic allodynia and hyperalgesia in the imiquimod (IMQ)-induced psoriasis mice model could be modulated by anti-inflammatory agents and compound 48/80 (C48/80) and to determine whether the activation of 5-HT1A receptor modulates these nociceptive behaviours. C57BL/6 male mice were treated with 5% IMQ for 7 days. The paw withdrawal responses to von Frey filaments (10 and 250 mN) were used to assess the allodynia and hyperalgesia. Nociceptive behaviours were also evaluated using ketorolac 15 mg/kg s.c., adalimumab 10 mg/kg s.c. and C48/80 10 mg/kg i.p. Then, the serum serotonin and the impact of 8-OH-DPAT (1 mg/kg s.c), a 5-HT1A receptor agonist, on long-lasting pain were examined. Mice receiving IMQ showed enhanced nociception, which decreased with all tested compounds. The serum serotonin in the IMQ group showed a significant decrease (947.042 ng/ml) regarding the control group (1143.68 ng/ml). The pretreatment with 8-OH-DPAT alleviated pain-related behaviours. These results suggest that the long-lasting pain resulting from psoriasis inflammation is also associated with the serotonergic system. The 5-HT1A receptor should be further explored as a potential therapeutic target for psoriasis pain modulation. |
| Databáze: | OpenAIRE |
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