PROLONGED SURVIVAL OF DISCORDANT PORCINE ISLET XENOGRAFTS1
| Autor: | Edward H. Finke, P. E. Lacy, R. Navalesi, David W. Scharp, Carol J. Swanson, Rosa Giannarelli, Barbara Olack, Piero Marchetti, D Gerasimidi-Vazeou |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Transplantation
Chemotherapy medicine.medical_specialty geography geography.geographical_feature_category Ratón business.industry medicine.medical_treatment Heterologous medicine.disease Islet Cryopreservation Endocrinology Diabetes mellitus Internal medicine medicine Collagenase business medicine.drug |
| Zdroj: | Transplantation. 61:1100-1102 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-199604150-00019 |
| Popis: | Purified porcine islets were prepared by collagenase digestion and density gradient purification, and transplanted under the kidney capsule of C57B/B6 mice with streptozotocin-induced diabetes which were receiving varying temporary immunosuppressive therapies. Islets that had been cultured for 1 day at 37 degree C were rejected after : 9+/-0.1 (mean+/-SE) days in control mice: 14+/-3 days in mice receiving mouse antilymphocyte serum (MLS) plus porcine antilymphocyte serum (PLS) on day of transplant (day 0); 43+/-6 days in mice treated for 1 week with anti-CD4 antibody (aCD4); 36+/-4 days in mice given aCD4 for 1 week plus PLS on days 0 and 7; 47+/-3 days in mice treated with aCD4 for 1 week plus MLS and PLS on day 21. Porcine islet survival in these latter three groups was significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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