Association Between Anticholinergic Drugs and Apolipoprotein E ɛ4 Allele and Poorer Cognitive Function in Older Cardiovascular Patients: A Cross-Sectional Study

Autor:	Hannu Kautiainen, Timo E. Strandberg, Juho Uusvaara, Reijo Tilvis, Kaisu Pitkälä, Pentti J. Tienari
Rok vydání:	2009
Předmět:	Apolipoprotein E Geriatrics medicine.medical_specialty Clinical Dementia Rating Cross-sectional study medicine.drug_class business.industry Cognitive disorder medicine.disease Comorbidity Internal medicine mental disorders Anticholinergic medicine Dementia Geriatrics and Gerontology business Psychiatry human activities
Zdroj:	Journal of the American Geriatrics Society. 57:427-431
ISSN:	1532-5415 0002-8614
DOI:	10.1111/j.1532-5415.2008.02129.x
Popis:	OBJECTIVES: To clarify the association between anticholinergic drugs and apolipoprotein E ɛ4 allele carrier status (APOE4) and cognitive dysfunction. DESIGN: Cross-sectional analyses of current drug use and cognitive functioning according to the baseline assessments of the Drugs and Evidence-Based Medicine in the Elderly Study. SETTING: Helsinki, Finland. PARTICIPANTS: Four hundred community-dwelling people aged 75 to 90 without clinical dementia but with a history of stable atherosclerotic disease. MEASUREMENTS: Cognitive function according to the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating Scale (CDR). Participants' use of anticholinergic drugs was estimated using definitions from previous scientific literature. APOE alleles determined from peripheral blood leukocyte deoxyribonucleic acid using standard polymerase chain reaction–based methods. RESULTS: There was an association between anticholinergic drugs and lower MMSE scores (P for trend
Databáze:	OpenAIRE
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