Comparative evaluation of the doses received by the parotid glands as predictors of xerostomia be 3D-CRT, IMRT and VMAT irradiation techniques in local advanced nasopharynx cancer
| Autor: | Dragoș Petru Teodor Iancu, Irina Butuc, Calin Buzea, Camil Ciprian Mireștean, Alexandru Zara |
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| Rok vydání: | 2017 |
| Předmět: |
Materials Science (miscellaneous)
medicine.medical_treatment Locally advanced 010403 inorganic & nuclear chemistry 01 natural sciences Industrial and Manufacturing Engineering 030218 nuclear medicine & medical imaging Comparative evaluation 03 medical and health sciences 0302 clinical medicine stomatognathic system medicine Business and International Management Nasopharyngeal cancer Contouring business.industry Head and neck cancer Cancer medicine.disease General Business Management and Accounting 0104 chemical sciences Parotid gland Radiation therapy stomatognathic diseases medicine.anatomical_structure General Agricultural and Biological Sciences Nuclear medicine business |
| Zdroj: | Archive of Clinical Cases. :146-153 |
| ISSN: | 2360-6975 |
| DOI: | 10.22551/2017.16.0403.10107 |
| Popis: | Xerostomia is commonly associated with the radio-chemotherapy treatment of the head and neck cancers. The risk increases with increasing doses received by the parotid. Severe xerostomia (defined as long-term salivary function of < 25% of baseline) may be avoided if at least one parotid gland receives less than 20 Gy. The combined treatment with cisplatin regarded as bringing a significant benefit in survival with concurrent radiotherapy is associated with increased risk of late toxicity. Intensity-modulated radiotherapy (IMRT) is considered the radio-therapeutic standard in the management of head and neck cancer. Purpose: to evaluate the possibility of modern techniques to reduce radiation doses to parotid glands compared to conventional 3D-CRT radiotherapy even if the parotid glands are not delineated as organs at risk (OAR) and dosimetric constraints are not applied. Methods: For 10 locally advanced nasopharyngeal cancer cases treated by radiotherapy with curative intent using 3D-CRT technique, alternative IMRT and VMAT plans were proposed without applying dosimetric constraints for parotid glands. Results: IMRT and VMAT techniques reduce the maximum dose (Dmax) and the mean dose (Dmean) for both parotid glands compared to the 3D-CRT technique. The treatment plans were comparatively analyzed in terms of doses received by both parotid glands. Conclusions: Modern radiotherapy techniques implementation can reduce the dose received by the parotids even in the absence of contouring them as organs at risk, reducing xerostomia and ensuring a better quality of life for the nasopharynx cancer radio-treated patients. |
| Databáze: | OpenAIRE |
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