| Autor: |
Luis A. Salazar, Jaime R. Silva, Jorge A Sanhueza, Christian L Herrera |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Revista médica de Chile. 139:1261-1268 |
| ISSN: |
0034-9887 |
| DOI: |
10.4067/s0034-98872011001000003 |
| Popis: |
Background: Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating. Aim: To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction. Material and Methods: The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively. Results: There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism. Conclusions: The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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