Hb Las Palms or α2β249(Cd8)Ser→Phe, a Mildly Unstable Hemiglobin Variant

Autor:	M. I. Balda-Aguirre, J. J. Malcorra-Azpiazu, Titus H.J. Huisman, J. C. Diaz-Chico, Ferdane Kutlar, Abdullah Kutlar, H. Hu, J. B. Wilson, Brooke B. Webber
Rok vydání:	1988
Předmět:	Genetics Biochemistry (medical) Clinical Biochemistry Family living Hemoglobin variants Hematology Biology medicine.disease Molecular biology High-performance liquid chromatography Hemoglobinopathy medicine Polyacrylamide gel electrophoresis Genetics (clinical) CD8
Zdroj:	Hemoglobin. 12:163-170
ISSN:	1532-432X 0363-0269
DOI:	10.3109/03630268808998022
Popis:	A new hemoglobin variant with a Ser→Phe substitution at position β 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45%, respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aaf1e1b24ebed2af1126db4490642a4f https://doi.org/10.3109/03630268808998022 Zobrazit plný text záznamu