Autor:	S. V. Litvinova, I. A. Kostanyan, V. V. Shul'govskii, Terebilina Nn, A. L. Kalyuzhnyi, Leonid F. Panchenko, V. V. Aristova
Rok vydání:	2003
Předmět:	medicine.medical_specialty Catabolism Offspring Chemistry Regulator Enkephalinase Endogeny General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Endocrinology Internal medicine medicine Morphine Homeostasis medicine.drug Endogenous opioid
Zdroj:	Bulletin of Experimental Biology and Medicine. 135:133-135
ISSN:	0007-4888
DOI:	10.1023/a:1023807512200
Popis:	We studied the effect of bioactive peptide HLDF-6 on functional activity of the endogenous antinociceptive system in the offspring of morphine-tolerant animals. Disturbances in this system included changes in the thermonociceptive threshold and enkephalinase A activity in various brain structures. The peptide acted as a potent regulator of the homeostasis in systems responsible for the synthesis and catabolism of endogenous opioids. HLDF-6 effectively corrected disorders of the endogenous antinociceptive system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aaf0b203534ab369ea338bf3a673b0ed https://doi.org/10.1023/a:1023807512200 Zobrazit plný text záznamu Full text from SpringerLink