The first asymmetric synthesis of (2S)- and (2R)-amino-3,3-dimethoxypropanoic acid

Autor:	Duane E. DeMong, Robert M. Williams
Rok vydání:	2002
Předmět:	chemistry.chemical_compound Trimethyl orthoformate Quenching (fluorescence) chemistry Stereochemistry Yield (chemistry) Organic Chemistry Drug Discovery Glycine Enantioselective synthesis chemistry.chemical_element Biochemistry Titanium
Zdroj:	Tetrahedron Letters. 43:2355-2357
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(02)00269-1
Popis:	The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (α-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with trimethyl orthoformate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aaf06d6ab3177c8af284a3c61a71fce6 https://doi.org/10.1016/s0040-4039(02)00269-1 Zobrazit plný text záznamu Full Text from ScienceDirect